Research is at the core of our technology advancements

Our extensive preclinical and pilot clinical work, over several years, has enabled us to model successful pivotal trials of the scanner. Our published research and ongoing clinical trials are part of our company culture and continue to validate our technology and help us understand the significant implications for breast health assessment.

Scientific Papers

The QT Imaging team includes medical doctors, engineers, and scientists. This esteemed group of professionals has authored and published many important papers on transmission ultrasound in the field.

Ultralow-Frequency Transmitted Ultrasound Tomography/Volography

Breast Glandular and Ductal Volume Changes during the Menstrual Cycle: A Study in 48 Breasts Using Ultralow- Frequency Transmitted Ultrasound Tomography/Volography

May 19, 2024

JamesWiskin, John Klock and Susan Love. Special Issue: Breakthroughs in Breast Radiology, Tomography 2024, 10, 789–805

Read the Paper

Biot Slow Wave

Quantitative data analysis and multiparameter inversion of Biot wave data: insights from topology and geometry

May 6, 2024

J. Wiskin and J. Klock. Quantitative data analysis and multiparameter inversion of Biot wave data: insights from topology and geometry

vol. 12932: SPIE, Medical Imaging 2024.

Read the Paper

Prostate Cancer Study

A New Look: The Promising Use of 3-Dimensional Quantitative Transmission Ultrasound Tomography for the Detection of Prostate Cancer: An Ex Vivo Study

May 4, 2024

S. H. Parikh, C. Hesswani, W. S. Azar, C. R. Koller, K. C. Schuppe, A. P. Kenigsberg, et al., “MP30-01 A NEW LOOK: THE PROMISING USE OF 3-DIMENSIONAL QUANTITATIVE TRANSMISSION ULTRASOUND TOMOGRAPHY FOR THE DETECTION OF PROSTATE CANCER AN EX VIVO STUDY,”

Journal of Urology, vol. 211, p. e490, 2024.

Read the Paper

3D Ultrasound Tomography

Quantitative data analysis and multiparameter inversion of Biot wave data: insights from topology and geometry

February 19, 2024

James Wiskin, John Klock. Presented at SPIE Medical Imaging Conference, Feb. 19-22, 2024

Read the Paper

Ultrasonic Imaging

Spectral-based Quantitative Ultrasound Imaging Processing Techniques: Comparisons of RF Versus IQ Approaches

February 6, 2024

M. Liu, Z. Kou, Y. Zhao, J. W. Wiskin, G. J. Czarnota, and M. L. Oelze, “Spectral-based Quantitative Ultrasound Imaging Processing Techniques: Comparisons of RF Versus IQ Approaches,” Ultrasonic Imaging, vol. 0, p. 01617346231226224, 2024 2024.

Read the Paper

Academic Radiology

A Multireader Multicase (MRMC) Receiver Operating Characteristic (ROC) Study Evaluating Noninferiority of Quantitative Transmission (QT) Ultrasound to Digital Breast Tomosynthesis (DBT) on Detection and Recall of Breast Lesions

January 29, 2024

A Multireader Multicase (MRMC) Receiver Operating Characteristic (ROC) Study Evaluating Noninferiority of Quantitative Transmission (QT) Ultrasound to Digital Breast Tomosynthesis (DBT) on Detection and Recall of Breast Lesions

Read the Paper

IEEE

2023 IEEE International Ultrasonics Symposium (IUS)

November 7, 2023

J. Wiskin and J. Klock, “Evidence for slow Biot wave tomography,” in 2023 IEEE International Ultrasonics Symposium (IUS), 2023, pp. 1-4.

Read the Paper

Academic Radiology

Whole body imaging using low frequency transmission ultrasound

Wiskin J, Malik B, Ruoff C, Pirshaffiey N, Klock J. Whole body imaging using low frequency transmission ultrasound. Academic Radiology 2023

Read the Paper

Zeitschrift für Medizinische Physik

Low frequency 3D transmission ultrasound tomography: technical details and clinical implications

J. Wiskin, B. Malik, and J. Klock, “Low frequency 3D transmission ultrasound tomography: technical details and clinical implications,” Zeitschrift für Medizinische Physik, 2023/06/07.

Read the Paper

Quantitative Ultrasound in Soft Tissues

Full Wave Inversion and Inverse Scattering in Ultrasound Tomography/Volography

J. Wiskin, “Full Wave Inversion and Inverse Scattering in Ultrasound Tomography/Volography,” in Quantitative Ultrasound in Soft Tissues, J. Mamou and M. L. Oelze, Eds., ed Cham: Springer International Publishing, 2023, pp. 201-237.

Read the Paper

Quantitative Ultrasound in Soft Tissues

Clinical Importance of 3D Volography in Breast Imaging

J. Klock, “Clinical Importance of 3D Volography in Breast Imaging,” in Quantitative Ultrasound in Soft Tissues, J. Mamou and M. L. Oelze, Eds., ed Cham: Springer International Publishing, 2023, pp. 239-249.

Read the Paper

High resolution segmentation of ductal, glandular and structural tissue: preliminary basis for collaboration with S. Love Foundation

April 4, 2022

James WiskinJohn KlockBilal MalikSusan Love

Proceedings Volume PC12038, Medical Imaging 2022: Ultrasonic Imaging and Tomography; PC120380 (2022) https://doi.org/10.1117/12.2612630

3D ultrasound tomography (3D-UT, or volography) gives heretofore unavailable resolution and accuracy in the 3D measurement of fibroglandular tissue in breast. The correct segmentation of the fibroglandular tissue requires an accurate high resolution speed of sound map which 3D UT (volography) produces and a robust segmentation algorithm. Our threshold based and Fuzzy C-means based algorithms have been compared and validated visually and with phantoms, and we show the effect of a row/column of dropouts on our reconstructions is minimal and indicate a variation of the volume of fibroglandular tissue in a variety of physiological situations for a select set of cases out of a larger 48 case cohort. We isolate glandular from ductal and structural tissue.

HighResolutionSegmentationDuctalGlandular

Quantitative Analysis of array dropouts in 3D Ultrasound tomography/volography

J. Wiskin and J. Klock, “Quantitative Analysis of array dropouts in 3D Ultrasound tomography/volography,” in 2022 IEEE International Ultrasonics Symposium (IUS), 2022, pp. 1-4.

10.1109/IUS54386.2022.9958866

IEEE

3D Ultrasound tomography timing validation for clinical deployment

December 1, 2022

J.  Wiskin and J. Klock, “3D Ultrasound tomography timing validation for clinical deployment,” in 2022 IEEE International Ultrasonics Symposium (IUS), 2022, pp. 1-3.
10.1109/IUS54386.2022.9957317

Ultrasound tomography as a gauge invariant fully connected convolutional neural network: repercussions

Ultrasound tomography as a gauge invariant fully connected convolutional neural network: repercussions
James Wiskin
Proceedings Volume PC12038, Medical Imaging 2022: Ultrasonic Imaging and Tomography; PC120380 (2022) https://doi.org/10.1117/12.2610822

UltrasoundTomographyAsGaugeInvariantFullyConnectedNN

Imaging of prostate cancer with 3D ultrasound tomography

April 4, 2022

James Wiskin, Jacob Enders, Cheyenne Williams, Ismail Turkbey, Michael Rothberg, Michael Daneshvar, Maria Merino, Sheng Xu, Emad Boctor, Yixuan Wu, Antoun Toubaji, Ayele Negussie, John Klock, Brad Wood, Peter Pinto

Proceedings Volume PC12038, Medical Imaging 2022: Ultrasonic Imaging and Tomography; PC120380 (2022)

https://www.spiedigitallibrary.org/conference-proceedings-of-spie/PC12038/PC120380/Imaging-of-prostate-cancer-with-3D-ultrasound-tomography/10.1117/12.2611811.short

Abstract PS3-15: Imaging of the distribution of human breast ducts

S. M. Love, J. Klock, and J. Wiskin, “Abstract PS3-15: Imaging of the distribution of human breast ducts,” Cancer Research, vol. 81, pp. PS3-15, 2021.

https://doi.org/10.1158/1538-7445.SABCS20-PS3-15

Mammographic density, 2D vs 3D methods: quantitative analysis of difference

February 15, 2021

James WiskinJohn KlockMartin CwiklaSanghyeb LeeBilal Malik

Proceedings Volume 11602, Medical Imaging 2021: Ultrasonic Imaging and Tomography; 116020E (2021) https://doi.org/10.1117/12.2581964

MammographicDensity,2Dvs3DMethods

PROSTATE ULTRASOUND TOMOGRAPHY (UT): CORRELATION WITH MRI AND WHOLE MOUNT HISTOPATHOLOGY

C. Williams, M. Daneshvar, Y. Wu, J. Owens-Walton, N. Yerram, P. T. Gomella, et al., “MP22-17 PROSTATE ULTRASOUND TOMOGRAPHY (UT): CORRELATION WITH MRI AND WHOLE MOUNT HISTOPATHOLOGY,” Journal of Urology, vol. 206, pp. e398-e398, 2021.

https://doi.org/10.1097/JU.0000000000002013.17

Analysis of timing results for 3D inverse scattering using transmission ultrasound

February 15, 2021

J. WiskinM. CwiklaJ. Klock

Proceedings Volume 11602, Medical Imaging 2021: Ultrasonic Imaging and Tomography; 116020G (2021) https://doi.org/10.1117/12.2581995

SPIEPresentation and Paper Timing2021

Orthopedic and myopathic imaging with transmission ultrasound tomography: experimental verification, quantitative accuracy and clinical implications

March 16, 2020

James WiskinBilal MalikVeena TheendakaraJohn Klock

Proceedings Volume 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography; 113190W (2020) https://doi.org/10.1117/12.2549759

SPIE Presentation and Paper Myopathic Imaging2020

Quantitative Breast Density (QBD) estimation with 3D transmission ultrasound and incomplete information

March 16, 2020

Quantitative Breast Density (QBD) estimation with 3D transmission ultrasound and incomplete information

James WiskinSam LeeMartin CwiklaBilal Malik

Proceedings Volume 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography; 113190D (2020) https://doi.org/10.1117/12.2549837

Limited view reconstructions with transmission ultrasound tomography: clinical implications and quantitative accuracy

March 16, 2020

QBDwithIncompletePresentationandPaper2020

Limited view reconstructions with transmission ultrasound tomography: clinical implications and quantitative accuracy

James WiskinBilal MalikNasser PirshafieyJohn Klock

Proceedings Volume 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography; 113190V (2020) https://doi.org/10.1117/12.2549704

LimitedView2020

Quantitative assessment of breast density using transmission ultrasound: comparison to MRI-based breast density

B. H. Malik, Y. Zhang, J. H. Chen, M. Y. Su, and J. W. Wiskin, “Quantitative assessment of breast density using transmission ultrasound: comparison to MRI-based breast density,” in 2020 IEEE International Ultrasonics Symposium (IUS), 2020, pp. 1-2.

10.1109/IUS46767.2020.9251384

Clustering based quantitative breast density assessment using 3D transmission ultrasound

March 16, 2020

Clustering based quantitative breast density assessment using 3D transmission ultrasound

Bilal MalikSanghyeb LeeRajni NatesanJames Wiskin

Proceedings Volume 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography; 113190H (2020) https://doi.org/10.1117/12.2543069

Clustering Based QUS

3D inverse scattering in wholebody ultrasound applications (Conference Presentation)

3D inverse scattering in wholebody ultrasound applications (Conference Presentation)

Mark LenoxJohn KlockCathy RuoffNasser PirshaifeyRobin TerryBilal MalikJames Wiskin

Proceedings Volume 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography; 1095511 (2019) https://doi.org/10.1117/12.2512575

3D inverse scattering Presentation

Academic Radiology

An Exploratory Multi-reader, Multi-case Study Comparing Transmission Ultrasound to Mammography on Recall Rates and Detection Rates for Breast Cancer Lesions

December 3, 2020
Nature Research - Scientific Reports

Full wave 3D inverse scattering transmission ultrasound tomography in the presence of high contrast

November 19, 2020
SPIE Medical Imaging 2020 Abstract

Orthopedic and myopathic imaging with 3D transmission ultrasound tomography: experimental verification, quantitative accuracy and clinical implications

February 17, 2020
SPIE Medical Imaging 2020 Abstract

Limited view reconstructions with 3D transmission ultrasound tomography: clinical implications and quantitative accuracy

February 17, 2020
SPIE Medical Imaging 2020 Abstract

Clustering-based quantitative breast density assessment using 3D transmission ultrasound

February 16, 2020
SPIE Medical Imaging 2020 Abstract

Quantitative Breast Density (QBD) estimation with 3D transmission ultrasound and incomplete information

February 16, 2020
RSNA 2019 Abstract

Radiomics in Transmission Ultrasound Improve Differentiation between Benign and Malignant Breast Masses

December 3, 2019
RSNA 2019 Abstract

3D Printing of Whole Breast and Individual Breast Tissue Types based on Transmission Ultrasound

December 4, 2019
RSNA 2019 Abstract

Application of Machine Learning in the Calculation of Breast Density Using Transmission Ultrasound: A Comparison with Automated Mammographic Assessment

December 2, 2019
AACR

Quantitative assessment of breast density: transmission ultrasound is comparable to mammography with tomosynthesis

October 23, 2019

Rajni Natesan, James Wiskin, Sanghyeb Lee and Bilal H Malik

Elevated breast density is among the strongest independent predictors of breast cancer. Breast density scores are critical inputs in models used to calculate a patient’s lifetime risk of developing breast cancer. Today, the only FDA-cleared technology for assessing breast density uses mammography. An alternative modality for breast density quantification is 3D transmission ultrasound (TU). In this retrospective study, we compared automated breast density calculations derived from TU using Quantitative Breast Density (QBD) and mammography with tomosynthesis using VolparaDensity 3.1 for 225 breasts.

Click here to read the published research

RSNA 2018 Abstract

Accuracy of Volumetric Measurements in the Breast: A Study of Comparing Ultrasound Tomography and Hand-Held Ultrasound

IBDW2019

AI-based Quantitative Breast Density Assessment Using Transmission Ultrasound

June 16, 2019

Bilal Malik1, Rajni Natesan1,2, Sanghyeb Lee1, and James Wiskin1

1QT Ultrasound Labs, Novato, CA
2MD Anderson Cancer Center, Houston, TX

A growing body of evidence indicates that breast density is one of the most important independent risk factors of breast cancer. Currently, mammography is the only FDA‐cleared means to evaluate breast density in a general screening population.

We present 3D transmission ultrasound as a method to visualize and differentiate fibroglandular tissue within the breast and use a fully automated segmentation method machine learning‐based method to quantitatively assess the breast density. The results indicate that breast density as assessed by fully automated means using TU can be of significant clinical value and play an important role in breast cancer risk assessment.

Click here to view the presentation.

SPIE

Initial Progress on Whole Body QT Applications

April 23, 2019

Mark Lenox, John Klock, Cathy Ruoff, Nasser Pirshaifey, Robin Terry, Bilal Malik, and James Wiskin “3D inverse scattering in wholebody ultrasound applications (Conference Presentation)”, Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 1095511 (15 March 2019); doi: 10.1117/12.2512575.

Click here to read the research paper

Correlation of ultrasound tomography to MRI and pathology for the detection of prostate cancer

March 15, 2019

Correlation of ultrasound tomography to MRI and pathology for the detection of prostate cancer

Reza SeifabadiAlexis ChengBilal MalikShun KishimotoJames WiskinJeeva MunasingheAyele NegussieIvane BakhutashviliMurali KrishnaPeter ChoykePeter PintoArman RahmimEmad BoctorMaria MerinoMark LenoxBaris TurkbeyBradford Wood

Proceedings Volume 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography; 109550C (2019) https://doi.org/10.1117/12.2512001

CorrelationProstateMRI

Medical Physics

Quantitative Assessment of Breast Density Using Transmission Ultrasound Tomography

March 20, 2019

James Wiskin, Bilal Malik, Rajni Natesan, Mark Lenox

Breast density is important in the evaluation of breast cancer risk. This work demonstrates that the QBD algorithm has promise as a viable method to accurately and consistently quantify breast density. Additional work is required to further define the utility of the QBD algorithm in a clinical setting.

Click here to read the published research

SPIE

Radiologic-pathologic Validation of Transmission Ultrasound Tomography Using Microscopy with UV Surface Excitation

February 19, 2019

Bilal Malik1, Austin Todd2, Alyson Terry1, Farzad Fereidouni2, Rajni Natesan1, John Klock1, James Wiskin1, Mark Lenox1, Richard Levenson2

  1. 1. QT Ultrasound Labs, Novato, CA
  2. 2. Department of Pathology and Lab Medicine, UC Davis, Sacramento, CA

This study proves that full 3D transmission ultrasound has a remarkable ability in identification of breast anatomical structures.  Multimodality comparison also shows that transmission ultrasound tomography can be useful in understanding breast anatomy and physiology.

Click here to read the research paper

 

3D full inverse scattering ultrasound tomography of the human knee (Conference Presentation)

March 19, 2019

3D full inverse scattering ultrasound tomography of the human knee (Conference Presentation)

James WiskinBilal MalikRajni NatesanNasser PirshafieyJohn KlockMark Lenox

Proceedings Volume 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography; 109550K (2019) https://doi.org/10.1117/12.2512595

3D full inverse scattering ultrasound tomography of knee

Full wave 3D inverse scattering: 21st century technology for whole body imaging

J. Wiskin, B. Malik, R. Natesan, N. Pirshafiey, M. Lenox, and J. Klock, “Full wave 3D inverse scattering: 21st century technology for whole body imaging,” The Journal of the Acoustical Society of America, vol. 145, pp. 1857-1857, 2019.

https://doi.org/10.1121/1.5101706

SPIE

Transmission Ultrasound Imaging of the Human Knee

February 17, 2019

James W. Wiskin, Bilal Malik, Rajni Natesan, Nasser Pirshafiey, John Klock, and Mark Lenox “3D full inverse scattering ultrasound tomography of the human knee (Conference Presentation)”, Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 109550K (15 March 2019); doi: 10.1117/12.2512595

In this study of full wave 3D ultrasound tomography of the knee, we found:

Even in the presence of bone, full 3D inverse scattering transmission ultrasound gives quantitative estimates of tissue characteristics
– Tendons, ligaments, cartilage, muscle, fat
– Acoustic energy interacts with tissue at super-molecular level, giving tissue characteristics unavailable with other modalities
– Periosteum, cortical thickness

Even in presence of bone, fused transmission and reflection images
– Speckle free –refraction corrected/compounded over 360 degrees
– High resolution
– Consistent over time

Click here to download the research paper

eBook: Emerging Trends in Ultrasound

Transmission Ultrasound Imaging Using 3D Inverse Scattering

June 30, 2018

John C. Klock, Mark W Lenox, Bilal H. Malik, Rajni Natesan

Full 3D inverse scattering ultrasound tomography is a novel method unused by others in medical imaging. The technology has a unique mechanical architecture capable of acquiring speed of sound and reflection images in 3D. The image reconstruction is computationally challenging and involves solving complex equations using high-performance computing. Laboratory studies demonstrate that the technique has high resolution and high contrast-to-noise ratios in both speed and reflection images. Clinical studies show that this technology is capable of visualizing breast microanatomy and breast microcalcifications along with providing a method for tissue classification using biomarkers. Finally, the technology has improved performance for imaging dense breasts. Full 3D inverse scattering ultrasound tomography offers unparalleled imaging of the breast including microanatomic features of the breast.

Read the full article

Academic Radiology

Breast Cyst Fluid Analysis Correlations with Speed of Sound Using Transmission Ultrasound

March 27, 2018

Bilal H. Malik, PhD, John C. Klock, MD

The speed of sound of breast macrocysts, as observed using transmission ultrasound, correlated with the cytological features of intracystic cell clumps. On the basis of this  work with speed as a classifier, we propose a spectrum of breast macrocysts from fluid-filled to highly cellular. Our results suggest high-speed cysts are mature macrocysts with high cell counts and many cellular clumps that correlate with cyst microanatomy as seen by transmission ultrasound.

Click here to read the research paper

 

AAPM Medical Physics

Quantitative transmission ultrasound tomography: Imaging and performance characteristics

March 29, 2018

Bilal Malik, Robin Terry, James Wiskin, Mark Lenox

Quantitative Transmission (QT) ultrasound has shown promise as a breast imaging modality. This study characterizes the performance of the latest generation of QT ultrasound scanners: QTScanner 2000. The results show an improvement in the imaging performance of the system in comparison to earlier ultrasound tomography systems, which are applicable to clinical applications of the system, such as breast imaging.

Click here to read the research paper

 

 

BAOJ Clinical Trials

Visual Grading Assessment of Quantitative Transmission Ultrasound Compared to Digital X-ray Mammography and Hand-held Ultrasound in Identifying Ten Breast Anatomical Structures

August 8, 2017

John C. Klock, Elaine Iuanow, Kathleen Smith, and Nancy A. Obuchowski

We performed visual grading analysis studies comparing transmission ultrasound, digital x-ray mammography and hand-held ultrasound when visualizing ten normal breast anatomic structures. To compare the image quality of the three modalities, multiple readers scored the image quality of transmission ultrasound compared to the other two modalities using an ordinal rating scale. The study showed that transmission ultrasound can adequately see all the major anatomical features of the human breast, including ductal and glandular tissue detail, even in dense breasts.

Click here to read the research paper

Academic Radiology

Accuracy of Cyst vs. Solid Diagnosis in the Breast Using Quantitative Transmission (QT) Ultrasound

May 23, 2017

Elaine Iuanow, Kathleen Smith, Nancy A. Obuchowski, Jennifer Bullen, John C. Glock

This study shows the ability of QT ultrasound to determine whether a breast lesion is a cyst or a solid. QT ultrasound imaging was performed as adjunct to mammography. A total of fourteen readers evaluated the images. The results show that QT ultrasound provides an accurate assessment of a cyst versus a solid lesion in the breast.

Click here to read the research paper

 

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

3D Nonlinear Acoustic Inverse Scattering: Algorithm and Quantitative Results

May 23, 2017

James Wiskin, David Borup, Elaine Iuanow, John C. Klock, Mark Lenox

In this paper, we describe the technical details of our image reconstruction algorithm. We show that the 3D inversion algorithm provides a more detailed image when compared to 2D algorithms, which results in a clearer depiction of the breast anatomy and lesions.

Click here to read the research paper


Caption: Speed of sound image of a phantom using (left) 2D image reconstruction and (right) 3D reconstruction

Quantitative 3D high resolution transmission ultrasound tomography: creating clinically relevant images (Conference Presentation)

May 2, 2017

Quantitative 3D high resolution transmission ultrasound tomography: creating clinically relevant images (Conference Presentation)

James WiskinJohn KlockElaine IuanowDave BorupRobin TerryBilal MalikMark Lenox

Proceedings Volume 10139, Medical Imaging 2017: Ultrasonic Imaging and Tomography; 101390Y (2017) https://doi.org/10.1117/12.2254639

Quant3DHighRes2017

Scientific Reports

Objective Breast Tissue Image Classification Using Quantitative Transmission Ultrasound Tomography

December 9, 2016

Bilal Malik, John C. Klock, James Wiskin, and Mark Lenox

We show that QT ultrasound is essentially a multi-modality imaging system that can differentiate between different breast tissue types such as skin, fat, glands, ducts and connective tissue. This study is a first step towards a computer aided detection/diagnosis platform for QT ultrasound.

Click here to read the research paper

The International Journal of Biomedical Imaging

Anatomy-Correlated Breast Imaging and Visual Grading Analysis Using Quantitative Transmission Ultrasound

September 5, 2016

John C. Klock, Elaine Iuanow, Bilal Malik, Nancy A. Obuchowski, James Wiskin, and Mark Lenox

Breast imaging performed using QT ultrasound can delineate anatomical structures within the breast. For many breast features such as skin, connective tissue, blood vessels and ductal units, QT ultrasound shows significantly better image quality in comparison to mammography.

Click here to read the research paper

The International Journal of Biomedical Imaging

Imaging Performance of Quantitative Transmission Ultrasound

October 8, 2015

Mark Lenox, James Wiskin, Matthew A. Lewis, Stephen Darrouzet, David Borup, and Scott Hsieh

We provide a metrics to characterize transmission ultrasound. We then use this metrics to measure the imaging performance of QT ultrasound. We evaluated a prototype QT scanner for its ability to perform both speed of sound and reflection imaging.

Click here to read the research paper

Quantitative three dimensional nonlinear inverse scattering and reflection breast imaging: Initial clinical results

J. Wiskin, D. Borup, E. Iuanow, J. Klock, and M. Lenox, “Quantitative three dimensional nonlinear inverse scattering and reflection breast imaging: Initial clinical results,” The Journal of the Acoustical Society of America, vol. 135, pp. 2155-2155, 2014.

https://doi.org/10.1121/1.4876989

Quantitative volumetric breast imaging with 3D inverse scatter computed tomography

M. Andre, J. Wiskin, D. Borup, S. Johnson, H. Ojeda-Fournier, and L. Olson, “Quantitative volumetric breast imaging with 3D inverse scatter computed tomography,” Conf Proc IEEE Eng Med Biol Soc, vol. 2012, pp. 1110-3, 2012

10.1109/EMBC.2012.6346129

Inverse scattering and refraction corrected reflection for breast cancer imaging

Inverse scattering and refraction corrected reflection for breast cancer imaging

J. WiskinD. BorupS. JohnsonM. BerggrenD. RobinsonJ. SmithJ. ChenY. PariskyJohn Klock

Proceedings Volume 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy; 76290K (2010) https://doi.org/10.1117/12.844910

InverseScattering Paper

1976 - 2019

Archive of Transmission Ultrasound Research Papers

1. J. F. Greenleaf, S. A. Johnson, S. L. Lee, G. T. Hermant, and E. H. Woo, “Algebraic Reconstruction of Spatial Distributions of Acoustic Absorption within Tissue from Their Two-Dimensional Acoustic Projections,” in Acoustical Holography: Volume 5, P. S. Green, Ed., ed Boston, MA: Springer US, 1974, pp. 591-603.

2. Wiskin, J. W., “Modelling of Acetylcholine Release from Neurons and Parameter Estimation”,Lect. in Applied Math, Vol. 19, American Math. Soc. , 1980.

3. S. A. Johnson, F. Stenger, C. Wilcox, J. Ball, and M. J. Berggren, “Wave Equations and Inverse Solutions for Soft Tissue,” in Acoustical Imaging, J. P. Powers, Ed., ed Boston, MA: Springer US, 1982, pp. 409-424.

4. S. A. Johnson and M. L. Tracy, “Inverse Scattering Solutions by a Sinc Basis, Multiple Source, Moment Method — Part I: Theory,” Ultrasonic Imaging, vol. 5, pp. 361-375, 1983.

5. S. A. Johnson, Y. Tae-Hoon, and R. Jung-Woong. (1983, Inverse scattering solutions of scalar Helmholtz wave equation by a multiple source moment method. Electronics Letters 19(4), 130-132. Available: http://digital-library.theiet.org/content/journals/10.1049/el_19830092

6. M. L. Tracy and S. A. Johnson, “Inverse scattering solutions by a sinc basis, multiple source, moment method — part II: Numerical evaluations,” Ultrasonic Imaging, vol. 5, pp. 376-392, 1983/10/01/ 1983.

7. S. A. Johnson, Y. Zhou, M. K. Tracy, M. J. Berggren, and F. Stenger, “Inverse scattering solutions by a sinc basis, multiple source, moment method — Part III: Fast algorithms,” Ultrasonic Imaging, vol. 6, pp. 103-116, 1984/01/01/ 1984.

8. Johnson, S.A., D.T. Borup, Wiskin, J. W., R.S. Eidens and M.J. Berggren, , “Imaging Shear and Bulk Elastic parameters in Three-Dimensions by fullwave, Non-Pertubative Inverse Scattering Tomography with Examples from Large Grids, Limited View Angles and Real Data,” Acoustic Imaging 18, 1989.

9. Wiskin, J. W., S.A. Johnson, D.T. Borup and M.J. Berggren, , “Non-pertubative Modeling and Inversion of Elastic and Acoustic inhomogeneous Structures Imbedded within a Layered Half Space,” SEG 1989 Summer Workshop, Snowbird, UT, Aug. 13–17, 1989.

10. Borup D. , S. Johnson, Wiskin, J. W. and M. Berggren, 1989, “Integral equation algorithms for imaging arbitrarily inhomogeneous distributions of elastic parameters imbedded in a homogeneous space,SEG 1989 Summer Workshop, Snowbird, UT, Aug. 13–17, 1989.

11. Seader, J.D., M. Kuno, W.J. Lin, Johnson, S. A. K. Unsworth and Wiskin, J., W., “Homotopy Continuation methods“, Computers and Chemical Engineering..Vol. 14, No. 1, pp. 71-85, 1990 — Winner Best Paper of 1990 Award.

12. Wiskin, J. W., “Geometric and Integral Equation Methods for Scattering in Layered Media”., Ph.D. Dissert., Dept. Math., University Microfilms International, Ann Arbor, MI., 1991.

13. Johnson, S. A., D. T. Borup, M J. Berggren, Wiskin, J. W., and R. S. Eidens, “Modeling of inverse scattering and other tomographic algorithms in conjunction with wide bandwidth acoustic transducer arrays for towed or autonomous sub-bottom imaging systems,” Proc. of Mastering the Oceans through Technology (Oceans 92) , Newport. R.I. Oct. 26-29, 1992, pp 294-299, 1992

14. S. A. Johnson, D. T. Borup, M. J. Berggren, J. W. Wiskin, R. Eidens, “Modeling of Inverse Scattering and Other Tomographic Algorithms in Conjuction with Wide Bandwidth Acoustic Transducer Arrays for Towed or Autonomous Sub-bottom Imaging Systems”, IEEE Oceans 92. Conference, Vol 1, pp. 294-299 (Oct 26-29, 1992).

15. S.A. Johnson, M.J. Berggren, D.T. Borup, J.W. Wiskin, R.S. Eidens, and H. Leng, “Comparison of Inverse Scattering and Other Tomographic Imaging Algorithms Using Simulated and Tank Data for Modeling Subbottom Imaging Systems,” IEEE Oceans ’93 Conference, October 18- 21, 1993 , Vol. I, pp. 458-492 (1993).

16. J.W. Wiskin, S.A. Johnson, D.T. Borup, M. Berggren, R. Eidens, Y. Zhang. “Full Inverse Scattering vs. Born-Like Approximation for Imaging in a Stratified Ocean”, IEEE Oceans ’93 Conference, Vol. III, pp. 450-455 (October 18-21, 1993).

17. Wiskin, J. W., S. A. Johnson, D. Borup, M. Berggren, and R. Eidens, “Full Inverse Scattering vs. Born-like Approximation for Imaging in a Stratified Ocean”, Proc. of Engineering in harmony with the Ocean (Oceans ’93), Victoria, British Columbia, Oct. 1993.

18. Johnson, S. A., D. T. Borup, M. J. Berggren, Wiskin, J. W., R. S. Eidens, 1993, “Comparison of Inverse Scattering and Other Tomographic Imaging Algorithms using simulated and Tank Data for Modeling Sub-bottom Imaging Systems,Proc. of Engineering in harmony with the Ocean (Oceans ’93), Victoria, British Columbia, Oct. 1993.

19. Wiskin, J.W., D. T. Borup, and S. A. Johnson, “Inverse Scattering from cylinders of arbitrary cross-section in Stratified Environments”, in Progress in Electromagnetics Research Symposium (PIERS), , p.195. July 24-28, University of Washington, Seattle, WA, 1995

20. Borup, D. T., S. A. Johnson, and J. W. Wiskin, FDTD and Integral Equation simulation of a Prototype Ultrasound Breast Scanner, in Progress in Electromagnetics Research Symposium, (PIERS) , p. 621, July 24-28, University of Washington, Seattle, WA, 1995

21. R.S. Eidens, J.W. Wiskin, D.T. Borup, S.A. Johnson, and M.J. Berggren, “Experimental Verification of Acoustic Inverse Scattering Tomography — Simple Phantoms,” submitted to IEEE UFFC.

22. Wiskin, J.W., D. T. Borup, and S. A. Johnson, “Inverse Scattering from cylinders of arbitrary cross-section in Stratified Environments”, in Progress in Electromagnetics Research Symposium (PIERS), July 24-28, 1995, University of Washington, Seattle, WA, p.195.

23. Borup, D. T., S. A. Johnson, and J. W. Wiskin, FDTD and Integral Equation simulation of a Prototype Ultrasound Breast Scanner, in Progress in Electromagnetics Research Symposium, (PIERS) July 24-28, 1995, University of Washington, Seattle, WA, pp. 621.

24. Steven A. Johnson, David T. Borup, James W. Wiskin, Michael J. Berggren, Michael S. Zhdanov, Kyle Bunch, and Richard Eidens, “Application of Inverse Scattering and Other Refraction Corrected methods to Environmental Imaging with Acoustic or Electromagnetic Energy”, in Next Generation Environmental models and computational methods., Ed. George Delic, Mary F. Wheeler, Proceedings of a U.S. Environmental Protection Agency sponsored workshop at the National Environmental Supercomputing Center. 1997 SIAM, pp 295-312. Libr. Congress Card No. 96-71103, ISBN 0-89871-378-1

25. Yuan, X. , J. W. Wiskin, D. T. Borup, M. Berggren, Rick Eidens, S. A. Johnson, “Formulation and Validation of Berenger’s PML Absorbing Boundary for the FDTD simulation of Acoustic Scattering”, IEEE Trans. UFFC. 44, 4, 1997 (IEEE Trans Ultrason., Ferro, Freq. Control..

26. Yuan, X., D. Borup D. T., Wiskin, J. W., Berggren, M., Johnson, S. A. and R. Eidens, “Simulation of acoustic wave propagation in dispersive media with relaxation losses by using FDTD methods with PML absorbing boundary condition”, accepted for publication, Trans. of Ultrasonics, Ferro., and Freq. Control.

27. J.W. Wiskin, D.T. Borup, and S.A. Johnson. “Inverse Scattering from cylinders of arbitrary cross-section in stratified environments via Green’s operator,” J. Acoust. Soc. Am., 102 (2), Pt.1, August, pp. 853-864, 1997..

28. Steven A. Johnson, David T. Borup, James W. Wiskin, Michael J. Berggren, Michael S. Zhdanov, Kyle Bunch, and Richard Eidens, “Application of Inverse Scattering and Other Refraction Corrected methods to Environmental Imaging with Acoustic or Electromagnetic Energy“, in Next Generation Environmental models and computational methods., Ed. George Delic, Mary F. Wheeler, Proceedings of a U.S. Environmental Protection Agency sponsored workshop at the National Environmental Supercomputing Center, S.I.A.M., 1997.

29. Wiskin, J. W., Borup, D. T., Johnson, S. A., “Inverse Scattering from cylinders of arbitrary cross-section in stratified environments via Green’s operator“, J. Acoust. Soc. America, 102 (2), Pt.1, August, pp. 853-864, 1997.

30. Yuan, X. ,Wiskin, J. W., D. T. Borup, M. Berggren, Rick Eidens, S. A. Johnson, “Formulation and Validation of Berenger’s PML Absorbing Boundary for the FDTD simulation of Acoustic Scattering”, IEEE Trans. UFFC. 44, 4, (IEEE Trans Ultrason., Ferro, Freq. Control.), 1997.

31. Wiskin, J. W, “Fast and accurate 3D acoustic propagation and inversion in layered media environments”, Canadian Acoustical Association Annual meeting, London, Ontario, Canada, and published in special issue of Canadian Acoustics/Acoustique Canadienne, Vol. 26, no. 3, September 1998, proceedings, cahiers des actes, Oct. 27-30, 1998.

32. J.W. Wiskin, D. Borup, S.A. Johnson. “Fast and Accurate Acoustic Propagation and Inversion in Layered Media Environments,” presented Oct. 27-30, 1998, at the Canadian Acoustic Association (CAA) Conference, in London, Ontario, Canada, Secretary of CAA, Ottawa, Ontario, Canada.

33. Steven A. Johnson, David T. Borup, James W. Wiskin, Michael Zhdanov, Edward Nichols and Ugo Conti, and Giuseppe Guarino. “Construction of CPT Hardware and Software for 3-D, EM Imaging of DNAPL by Quasi-Static Regime Methods,” 2nd Quadrennial Symposium on Three-Dimensional Electromagnetics (Symposium Honoring G Hohmann), Univ. of Utah, Oct. 26-29, 1999.

34. (ABSTRACT FOR INVITED TALK) S.A. Johnson, D.T. Borup, J.W. Wiskin: “Integrating Experimental Procedures with Algorithms for Practical Imaging by Full Wave, Nonlinear Inverse Scattering”. XXVIth General Assemble of International Union of Radio Science (U.S.R.I.). , Assemblee’ Ge’ne’rale de l’Union radio-scientifique internationale . Toronto, Ontario, Canada, August 13-21, 1999. Invited Lecture.

35. Wiskin, JW, Johnson, SA, Borup, DT., “Integrating Experimental Procedures with Algorithms for Practical Imaging by Full Wave, Non-Linear Inverse Scattering,” Invited Lecture (Presenting Author: J. Wiskin), Assemblee’ Generale de l’Union radio-scientifique internationale, XXVIth General Assembly of the International Union of Radio Science (U.R.S.I.), Aug. 13-21, Toronto, Ontario, Canada, 1999.

36. Yuan, X., D. Borup D. T., Wiskin, J. W., Berggren, M., Johnson, S. A. and R. Eidens, “Simulation of acoustic wave propagation in dispersive media with relaxation losses by using FDTD methods with PML absorbing boundary condition“, I.E.E.E. Trans. of Ultrasonics, Ferro., and Freq. Control., Vol 46, No. 1, January, 1999.

37. Wiskin, J.W., M. Zhdanov, D. T. Borup, S. A. Johnson, J. Riley, O. Portniaguine, “3-D EM Imaging in Quasi-Static regime, of Inhomogeneities in Ocean Sediment with Layered Green’s Functions: Experiment and Theory”, Second International Symposium on Three- Dimensional Electromagnetics, University of Utah, Salt Lake City, U.S.A., October 27-29, 1999.

38. Steven A. Johnson, David T. Borup, James W. Wiskin, Michael Zhdanov, O. Portniaguine, Edward Nichols, Ugo Conti and Giuseppe Guarino .”Construction of CPT Hardware and Software for 3-D, EM Imaging of DNAPL by Quasi-Static Regime Methods”, Second International Symposium on Three-Dimensional Electromagnetics, University of Utah, Salt Lake City, U.S.A., October 27-29, 1999

39. Johnson, S. A., D. T. Borup, J W. Wiskin, M. J. Berggren, T. Guillerm, and S C. Olsen, “Fast, non-perturbative, transmission inverse scattering, quantitative imaging with laboratory and simulated acoustic data”, Invited lecture at 139th Meeting of the Acoustical Society of America, May, 2000.

40. (ABSTRACT FOR INVITED TALK) S.A. Johnson, D.T. Borup, J.W. Wiskin, M.J. Berggren, T. Guillerum,:and S.C. Olsen. “Fast, nonperturbative, transmission inverse scattering, quantitative imaging with laboratory and simualt4dacoutic data”. Acoustical Soc. of Amer., 139th Meeting, 31 May 2000, Weston Peachtree Plaza, Atlanta, GA.

41. Wiskin, J. W,, Johnson, SA, Borup, DT., “Wave Propagation and Nonlinear Inversion in Layered or Moving Media – Fast Algorithms for High Contrasts,” Soc. Indust. Appl. Math. (SIAM) Annual Meeting, Proceedings, San Diego, California, July 9-13, 2001.

42. Johnson, SA, R. Hanover, DT Borup, JW Wiskin, M. Berggren, “Noninvasive Breast Tissue Characterization Using Ultrasound Speed and Attenuation: In Vivo Validation, Acoustical Imaging 28 Symposium in San Diego, California, March 20-23, 2005.

43. Johnson, S., D. T. Borup, J. W. Wiskin, Included section in Revision of ‘Image Reconstruction from Projections: The Fundamentals of Computerized Tomography’, Gabor T. Herman, Academic Press, New York, 2005.

44. Wiskin, JW, DT Borup, SA Johnson, M Berggren, T. Abbott, R. Hanover, “Full Wave Nonlinear Inverse Scattering: High Resolution Quantitative Breast Tissue Tomography”, Invited Talk at the 28th Acoustical Imaging Symposium in San Diego, California, March 20- 23, 2005.

45. Johnson, SA, R. Hanover, DT Borup, JW Wiskin, M Berggren, M Kammeyer, Scott Olsen, Jeff Pattee, F. Setinsek, K. Stewart, B. Hanover, “Design and first Clinical Implementation of the Ultrasound CT™ System for Breast Imaging”, Acoustical Imaging 28 Symposium in San Diego, California, March 20-23, 2005.

46. Wiskin, JW, Borup, DT, Johnson, SA, Berggren, M., Hanover, B., Setinsek, F., Hanover, R., Acoustic Inverse Scattering in Breast Imaging, 1st Annual Mountain West Biomedical Engineering Conference, Snowbird Cliff Lodge, Snowbird, Utah, Sept. 16-17th, 2005.

47. Steven A. Johnson, Robert Bell, Michael Berggren, David Borup, Barry Hanover, Rita Hanover, Martin Kammeyer, Scott Olsen, Jeffrey Pattee, David Robinson, Frank Setinsek, Kortlan Stewart, and James Wiskin. “DESIGN AND FIRST CLINICAL IMPLEMENTATION OF AN ULTRASOUND-CTTM SYSTEM FOR BREAST IMAGING”. 28th International Acoustical Imaging Symposium, San Diego, CA, USA, March 20-23, 2005. Plenum/Kluwer, Dordrecht, Netherlands. (written but not submitted).

48. Steven A. Johnson, Thomas Abbott, Robert Bell, Michael Berggren, David Borup, David Robinson, James Wiskin, Scott Olsen and Barry Hanover. “NONINVASIVE BREAST TISSUE CHARACTERIZATION USING ULTRASOUND ATTENUATION: IN VIVO VALIDATION”. 28th International Acoustical Imaging Symposium, San Diego, CA, USA, March 20-23, 2005. Plenum/Kluwer, Dordrecht, Netherlands.

49. J Wiskin, D.T. Borup, S.A. Johnson, M. Berggren , T. Abbott, R. Hanover. “FULL WAVE, NON-LINEAR, INVERSE SCATTERING: HIGH RESOLUTION QUANTITATIVE BREAST TISSUE TOMOGRAPHY”. 28th International Acoustical Imaging Symposium, San Diego, CA, USA, March 20-23, 2005. Plenum/Kluwer, Dordrecht, Netherlands.

50. Johnson, S.A., D.T Borup, J.W. Wiskin, M.J. Berggren, B. Hanover, F. Setinsek,, S.C. Olsen, K. Callahan, and staff. “From laboratory to clinical trails; an odyssey of ultrasound inverse scattering imaging for breast cancer diagnosis”, invited, 4th Joint meeting of the Acoustical Society of America and the Acoustical Society of Japan., 28 Nov.–02 Dec. 2006, Sheraton Waikiki Hotel, Honolulu, Hawaii.. Special session on: BIOMEDICAL ULTRASOUND/BIORESPONSE TO VIBRATION: (BB), Acoustic tomography in tissue., Nov. 2006.

51. Wiskin, J., D. Borup, S. Johnson, M. Berggren, B. Hanover, S. Olsen, F. Setinsek, R. Hanover, and TSI staff, Full wave nonlinear inverse scattering for transmission breast imaging, 4th JOINT MEETING OF THE ACOUSTICAL SOCIETY OF AMERICA AND THE ACOUSTICAL SOCIETY OF JAPAN 28, Special session on: BIOMEDICAL ULTRASOUND/BIORESPONSE TO VIBRATION: (BB), Acoustic tomography in tissue., Nov. 2006.

52. Andre, M.P. , C. Barker, N. Sekhon, L.K. Olson, D. Borup and J. Wiskin, Recent experience with ultrasound computed tomography for breast imaging, (invited), 32nd International Symposium on Ultrasonic Imaging and Tissue Characterization, May 16-18, Arlington, VA., 2007.

53. Wiskin, J. D. T. Borup, S.A. Johnson, M. Berggren, T. Abbott, R. Hanover, “Full-Wave, Non-linear, Inverse Scattering,” Acoustical Imaging, Vol. 28, p183-193,. M. Andre, editor, Springer, 2007

54. Johnson, S. T. Abbott, R. Bell, M Berggren, D. Borup, D. Robinson, J. Wiskin, S. Olsen, B. Hanover, “Non-Invasive Breast Tissue Characterization Using Ultrasound Speed and Attenuation,” , Acoustical Imaging, Vol. 28, p147-154, M. Andre, editor, Springer, 2007

55. Wiskin, J., D. Borup, S. A. Johnson, M. Berggren, F. Setinsek, B. Hanover, S. Olsen and K. Callahan, Multi-frequency, fully nonlinear, acoustic inverse scattering: theory and breast tissue characterization, 32nd International Symposium on Ultrasonic Imaging and Tissue Characterization, May 16-18, Arlington, VA. 2007.

56. Callahan, K.S., J.W. Wiskin, D.T. Borup, B. Hanover, S.A. Johnson and Y.R. Parisky, Representative patient case studies of speed of sound and attenuation of sound images from trans mission ultra sound imaging of the breast, 32nd International Symposium on Ultrasonic Imaging and Tissue Characterization, May 16-18, Arlington, VA. , 2007

57. Callahan, KS, DT Borup, SA Johnson, J Wiskin, Y Parisky, Transmission breast ultrasound Imaging representative case studies of speed of sound and attenuation of sound computed tomographic Images., 17th Annual National Interdisciplinary Breast Conference, Las Vegas, NV., Mar. 2007, Am Journ Clin Oncology

58. NONINVASIVE BREAST TISSUE CHARACTERIZATION USING ULTRASOUND SPEED AND ATTENUATION: IN VIVO VALIDATION. Steven A. Johnson, Thomas Abbott, Robert Bell, Michael Berggren, David Borup, David Robinson, James Wiskin, Scott Olsen and Barry Hanover. Acoustic Imaging (Text) 2007 Springer Verlag

59. Andre, M.P. , C. Barker, N. Sekhon, L.K. Olson, D. Borup and J. Wiskin, Recent experience with ultrasound computed tomography for breast imaging, (invited), 32nd International Symposium on Ultrasonic Imaging and Tissue Characterization, May 16-18, Arlington, VA., 2007.

60. Wiskin, J. D Borup, M Andre, S Johnson, B Hanover, K Callahan, F Setinsek, C Barker, S Olsen, M Berggren, Performance of an Automated Whole-Breast Ultrasound Imaging System Employing Full-Wave 3D Inverse-Scattering, RSNA 2008, Nov. 6, 2008

61. Wiskin, J., 3-D Imaging Molecular Diagnostics: Inverse Scattering Algorithms, James Wiskin, Ph.D., Invited talk at the AACC sponsored 40th Annual Oak Ridge Conference – Breakthrough Technologies for Clinical Diagnostics , The Fairmont, San José, CA., American Assoc. of Clinical Chemists, San Jose California, April 17 – 18, 2008.

62. M.P. Andre, C Barker, N Sekhon, J Wiskin, D Borup, K. Callahan: Pre-clinical experience with full-wave inverse scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging 29:73-80, Springer, Dordrecht, 2009.

63. Wiskin, J., D. Borup, S. Johnson, “Inverse Scattering, Theory”, Acoustical Imaging, 30, Monterey, Calif., 2009.

64. Wiskin, J., D. Borup, K. Callahan, Y. Parisky, J. Smith, M. Andre, S. Johnson, “Inverse Scattering, Results”, Acoustical Imaging 30, Monterey, Calif., 2009.

65. J. Wiskin; D. Borup; S. Johnson; M. Berggren; D. Robinson; J. Smith; J. Chen; Y. Parisky; John Klock, ‘Inverse scattering and refraction corrected reflection for breast cancer imaging’, Jan D’hooge; Stephen A. McAleavey, Eds., Proc. SPIE, 7629, 2010

66. Wiskin, JW, Borup, D., Johnson, SJ, Berggren, M., Smith, J. Callahan, K., ‘Quantitative Ultrasound Inverse Scattering and Tomographic Refraction Corrected B-Scan, American Institute of Ultrasound in Medicine (AIUM), March 27, 2010.

67. Borup, D., Wiskin, JW, Pelligretti, P., Brusaca, M., Hanover, B., Johnson, Berggren, Klock, J, ‘360 Degree Compounded, Refraction Corrected Reflection Images of Human Breast’, American Institute of Ultrasound in Medicine (AIUM), March 26, 2010.

68. M.P. Andre, C Barker, N Sekhon, J Wiskin, D Borup, K. Callahan: Pre-clinical experience with full-wave inverse scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging 29:73-80, Springer, Dordrecht, 2009.

69. J. Wiskin; D. Borup; S. Johnson; M. Berggren; D. Robinson; J. Smith; J. Chen; Y. Parisky; John Klock, ‘Inverse scattering and refraction corrected reflection for breast cancer imaging’, Jan D’hooge; Stephen A. McAleavey, Eds., Proc. SPIE, 7629, 2010

70. J. Wiskin, D. Borup, K. Callahan, Y. Parisky, J. Smith, M. André, S. Johnson, Inverse scattering Results, Acoustical Imaging 30, pp. 61-68, Springer, Dordrecht, 2011.

71. J. Wiskin, D. Borup, S. Johnson, Inverse scattering: Theory, Acoustical Imaging 30, pp. 53-59, Springer, Dordrecht, 2011.

72. Pellegretti, P, S Dellepiane, M. Vicari, M. Zani, M. Weigel, D. Borup, J. Wiskin, U. Saueressig, E. Kotter, and M. Langer A Clinical Experience of a Prototype Automated Breast Ultrasound System Combining Transmission and Reflection 3D Imaging, UFFC 2011-IEEE International Ultasonics Symposium Oct. 18-21, 2011, Session P3Ab, b Tomography.

73. Wiskin, JW, D Borup, M Andre, H Ojeda-Fournier, L Olson, D Robinson, S Johnson, “Quantitative Imaging via Inverse Scattering”, AAPM-COMP 2011, Ultrasound Scientific Session: Quantitative Imaging: TU-A-220-1, Moderators: J. Fowlkes M. Kolios

74. Wiskin, JW, D Borup, M Andre, L Olson, H Ojeda-Fournier, D Robinson, S Johnson, “3D Inverse Scattering and Refraction Corrected Reflection” AAPM-COMP 2011, Ultrasound Imaging Symposium – Advanced Clinical Systems Session TU-B-220-4

75. Andre, M. PhD, James Wiskin, PhD, Haydee Ojeda-Fournier, MD, Linda Olson, MD, David Borup, PhD, Melissa Ledgerwood, B.S., Steven Johnson, PhD, “Quantitative 3D Whole Breast Imaging with Transmission and Reflection Ultrasound” AAPM Ultrasound Imaging Symposium Breast Imaging and Guidance of Interventions

76. J. Wiskin, D. Borup, S. Johnson, Inverse scattering: Theory, Acoustical Imaging 30, pp. 53-59, Springer, Dordrecht, 2011.

77. J. Wiskin, D. Borup, K. Callahan, Y. Parisky, J. Smith, M. André, S. Johnson, Inverse scattering Results, Acoustical Imaging 30, pp. 61-68, Springer, Dordrecht, 2011.

78. Vicari M, Saueressig U., Wiskin, J. Pellegretti, P., Zani, M., Ivanovas, V., Windfuhr-Blum, M., Kroschel, J., Kotter E., and Langer, M., Automated Breast Ultrasound: MRI and Ultrasound CT Imaging Similarities, 19th Annual Meeting: International Society for Magnetic Resonance in Medicine, Palais des congres de Montreal, Montreal, Quebec, Canada, 2011

79. Andre, M, J. Wiskin et al., AIUM Annual Convention, New York, 2011, “Quantitative 3- Dimensional Whole-Breast Imaging With Transmission and Reflection Ultrasound”, Advanced Breast Imaging Symposium, Moderators: M. Andre and P. Carson, Ph.D.

80. J. Wiskin, D. Borup, K. Callahan, Y. Parisky, J. Smith, M. André, S. Johnson, Inverse scattering Results, Acoustical Imaging 30, pp. 61-68, Springer, Dordrecht, 2011.

81. J. Wiskin, D. Borup, S. Johnson, Inverse scattering: Theory, Acoustical Imaging 30, pp. 53-59, Springer, Dordrecht, 2011.

82. J. Wiskin, D. Borup, S. Johnson, M. Berggren, Non-linear inverse scattering: High resolution quantitative breast tissue tomography, J. Acoust. Soc. Am. 131, 3802 (2012); http://dx.doi.org/10.1121/1.3699240, (also in Vir. J. Bio. Phys. Res., Vol. 23, (10), Instrumentation and Development)

83. M André, J Wiskin, D. Borup, S. Johnson, H Ojeda-Fournier and L Olson, Quantitative Volumetric Breast Imaging with 3D Inverse Scatter Computed Tomography, Proceedings, Eng. Med. Biol. Soc. Conf., EMBC 12, San Diego, California, Aug. 28 – Sept. 1, 2012, peer reviewed Invited paper.

84. M André, J Wiskin, D. Borup, S. Johnson, H Ojeda-Fournier and L Olson, Quantitative Volumetric Breast Imaging with 3D Inverse Scatter Computed Tomography, Proceedings, Eng. Med. Biol. Soc. Conf., EMBC 12, San Diego, California, Aug. 28 – Sept. 1, 2012, peer reviewed Invited paper.

85. M André, J Wiskin, D. Borup, S. Johnson, H Ojeda-Fournier and L Olson, Quantitative Volumetric Breast Imaging with 3D Inverse Scatter Computed Tomography, Proceedings, Eng. Med. Biol. Soc. Conf., EMBC 12, San Diego, California, Aug. 28 – Sept. 1, 2012, peer reviewed Invited paper.

86. J. Wiskin, D. Borup, S. Johnson, M. Berggren, Non-linear inverse scattering: High resolution quantitative breast tissue tomography, J. Acoust. Soc. Am. 131, 3802 (2012); http://dx.doi.org/10.1121/1.3699240, (also in Vir. J. Bio. Phys. Res., Vol. 23, (10), Instrumentation and Development)

87. QTUS – Quantitative Transmission Ultrasound Volumetric Reflection Tomography. J. Wiskin, D. Borup, E. Iuanow, M. Lenox, J. Klock. Journal of the Acoustical Society of America 2014

88. GPU Accelerated Transmission Image Reconstruction for 3D Quantitative Ultrasound Breast Imaging. Qun(Maxine) Liu, Jim Hardwick, Dave Borup, Ph.D., Jim Wiskin, Ph.D. Nvidia Conference 2014

89. Mark W. Lenox, James Wiskin, Matthew A. Lewis, Stephen Darrouzet, David Borup, and Scott Hsieh. Imaging Performance of Quantitative Transmission Ultrasound; Hindawi Publishing Corporation International Journal of Biomedical Imaging vol. 2015; Article ID 454028. doi:10.1155/2015/454028

90. John C. Klock, Elaine Iuanow, BilalMalik, Nancy A. Obuchowski, JamesWiskin, and Mark Lenox. Anatomy-Correlated Breast Imaging and Visual Grading Analysis Using Quantitative Transmission Ultrasound. International Journal of Biomedical Imaging Volume 2016, Article ID 7570406, 9 pages http://dx.doi.org/10.1155/2016/7570406

91. Malik, B. et al. Objective breast tissue image classification using Quantitative Transmission ultrasound tomography. Nature Sci. Rep. 6, 38857; doi: 10.1038/srep38857 (2016).

92. Elaine Iuanow, MD, Kathleen Smith, MBA, Nancy A. Obuchowski PhD, Jennifer Bullen MSand John C. Klock, MD. Accuracy of Cyst vs. Solid Diagnosis in the Breast Using Quantitative Transmission (QT) Ultrasound. Academic Radiology 2017 Vol 24:1148-1153; doi: 10.1016/j.acra.2017.03.024. Epub 2017 May 23; PubMed ID 28549870. Academic Radiology has posted the study in full for free. http://www.healthimaging.com/topics/womens-health/breast-imaging/and-coming-ultrasound-technology-shows-prowess-mammography-adjunct.

93. John C Klock, Elaine Iuanow, Kathleen Smith, Nancy A and Obuchowski Visual Grading Assessment of Quantitative Transmission Ultrasound Compared to Digital X-ray Mammography and Hand-held Ultrasound in Identifying Ten Breast Anatomical Structures. BAOJ Clinical Trials 3: 015. (2017)

94. J. W. Wiskin, D. T. Borup, E. Iuanow, J. Klock, and M. W. Lenox; 3-D Nonlinear Acoustic Inverse Scattering: Algorithm and Quantitative Results; IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL In Press 2018

95. Bilal Malik, Robin Terry, James Wiskin, Mark Lenox; Quantitative transmission ultrasound tomography: Imaging and performance characteristics. Medical Physics. (2018). Click here to read the research paper

96. Bilal H. Malik, PhD, John C. Klock, MD; Breast Cyst Fluid Analysis Correlations with Speed of Sound Using Transmission Ultrasound. Academic Radiology. (2018). Click here to read the research paper

97. Rajni Natesan, Bilal Malik, Lauralyn R. Markle, Vashita Dhir, Robin Terry; Accuracy of Volumetric Measurements in the Breast: A Study of Comparing Ultrasound Tomography and Hand-Held Ultrasound. (2018). Click here to read the abstract.

98. Bilal Malik, Austin Todd, Alyson Terry, Farzad Fereidouni, Rajni Natesan, John Klock, James Wiskin, Mark Lenox, Richard Levenson; Radiologic-pathologic Validation of Transmission Ultrasound Tomography Using Microscopy with UV Surface Excitation (March 2019) Study available here.

99. James Wiskin, Bilal Malik, Rajni Natesan, Nasser Pirshafiey, John Klock, Mark Lenox; Transmission Ultrasound Imaging of the Human Knee. James W. Wiskin, Bilal Malik, Rajni Natesan, Nasser Pirshafiey, John Klock, and Mark Lenox “3D full inverse scattering ultrasound tomography of the human knee (Conference Presentation)”, Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 109550K (15 March 2019); doi: 10.1117/12.2512595 Study available for download here.

100. Mark Lenox, John Klock, Cathy Ruoff, Nasser Pirshaifey, Robin Terry, Bilal Malik, and James Wiskin “3D inverse scattering in wholebody ultrasound applications (Conference Presentation)”, Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 1095511 (15 March 2019); doi: 10.1117/12.2512575. Study available here.

101. James Wiskin, Bilal Malik, Rajni Natesan, Mark Lenox “Quantitative Assessment of Breast Density Using Transmission Ultrasound Tomography” (20 March 2019) Click here to read the published research.

102. Bilal Malik, Rajni Natesan, Sanghyeb Lee, James Wiskin; AI-based Quantitative Breast Density Assessment Using Transmission Ultrasound. (16 June 2019). Click here to view the presentation.

103. Bilal Malik, Sanghyeb Lee, James Wiskin, Rajni Natesan; Application of Machine Learning in the Calculation of Breast Density Using Transmission Ultrasound: A Comparison with Automated Mammographic Assessment. (2019). View Abstract

104. Bilal Malik, Nasser Pirshafiey, John C. Klock, Rajni Natesan; 3D Printing of Whole Breast and Individual Breast Tissue Types based on Transmission Ultrasound. (2019) View Abstract

105. Rajni Natesan, Sanghyeb Lee, Diane Navarro, Christopher Anaje, Bilal Malik; Radiomics in Transmission Ultrasound Improve Differentiation between Benign and Malignant Breast Masses. (2019). View Abstract

106. James W. Wiskin, Rajni Natesan, Sam Lee, Bilal Malik; Quantitative Breast Density (QBD) estimation with 3D transmission ultrasound and incomplete information. (2020). View Abstract

107. Bilal H. Malik, Sanghyeb Lee, Rajni Natesan, James W. Wiskin; Clustering-based quantitative breast density assessment using 3D transmission ultrasound. (2020). View Abstract

108. James W. Wiskin, Bilal Malik, Mark Lenox, Nasser Pirshafiey, Rajni Natesan, John Klock; Limited view reconstructions with 3D transmission ultrasound tomography: clinical implications and quantitative accuracy. (2020). View Abstract

109. James W. Wiskin, Bilal Malik, Veena Theendakara, Rajni Natesan, John Klock; Orthopedic and myopathic imaging with 3D transmission ultrasound tomography: experimental verification, quantitative accuracy and clinical implications. (2020). View Abstract

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